Adverse effects of long-term azithromycin use in patients
نویسندگان
چکیده
23 The adverse effects of azithromycin on the treatment of patients with chronic lung 24 diseases (CLD) were evaluated in the present study. 25 MEDLINE, and other databases were searched for relevant articles till August 2013. 26 Randomized controlled trials enrolled patients with chronic lung diseases who 27 received long-term azithromycin treatment were selected and data on microbiological 28 study and azithromycin-related adverse events were abstracted from articles and 29 analyzed. 30 Six studies were included in the meta-analysis. The risk of bacteria resistance in 31 patients receiving long-term azithromycin treatment was increased 2.7-fold [RR: 2.69 32 (95% CI 1.249, 5.211)] when compared with patients with placebo treatment. On the 33 opposite, the risk of bacteria colonization in patients receiving azithromycin treatment 34 decreased [RR: 0.551 (95% CI 0.460, 0.658)]. Patients with long-term azithromycin 35 therapy were at risk of increased impairment of hearing [RR: 1.168 (95% CI 1.030, 36 1.325)]. 37 This analysis provides evidence that supports the development of bacteria resistance 38 after receiving long-term azithromycin treatment. Besides the increasingly recognized 39 anti-inflammatory role of azithromycin used in chronic lung diseases, we should be 40 realized the potential adverse event of its long-term use. 41 42
منابع مشابه
The adverse effects of azithromycin on the treatment of patients with chronic lung
23 The adverse effects of azithromycin on the treatment of patients with chronic lung 24 diseases (CLD) were evaluated in the present study. 25 MEDLINE, and other databases were searched for relevant articles till August 2013. 26 Randomized controlled trials enrolled patients with chronic lung diseases who 27 received long-term azithromycin treatment were selected and data on microbiological 28...
متن کاملLong term effects of azithromycin in patients with cystic fibrosis: A double blind, placebo controlled trial.
BACKGROUND Macrolides display immunomodulatory effects that may be beneficial in chronic inflammatory pulmonary diseases. The aim of the study was to document whether long term use of azithromycin may be associated with respiratory benefits in young patients with cystic fibrosis. METHODS A multicentre, randomised, double blind, placebo controlled trial was conducted from October 2001 to June ...
متن کاملAssessing the performance of the HAS-BLED score: is the C statistic sufficient?
We thank Dr Vos and colleagues for providing important additional studies that support the use of long-term azithromycin therapy to treat and, possibly, prevent posttransplant bronchiolitis obliterans syndrome (BOS). These studies should have been included in our review of chronic macrolide therapy in infl ammatory airways disease 1 but were not available at the time of submission. Their recent...
متن کاملAzithromycin in Pityriasis Rosea: A Double-Blind, Placebo-Controlled Clinical Trial
Background: Pityriasis rosea is an inflammatory skin disorder with a known response to erythromycin. Considering similarities between erythromycin and azithromycin and lesser adverse effects of the latter, in a pilot study, we gave azithromycin to seven patients with pityriasis rosea and observed a noticeable improvement. The aim of this study was to evaluate the efficacy of azithromycin ...
متن کاملAzithromycin suppressed relapses of idiopathic nephrotic syndrome in a child
Long-term immunosuppressive therapy with severe adverse effects is indispensable to maintain disease remission in frequently relapsing nephrotic syndrome (NS) in children. Hence, development of new therapy with less toxicity for relapses of NS is required. We demonstrated a case of a 2-year-old boy with frequently relapsing NS, whose frequent relapses were successfully treated with azithromycin...
متن کامل